Spatially Resolved Spectroscopy Analysis of Powders: Experiments and Modeling
When measuring powders with an optical setup, one of the most important aspects is to understand the behavior of light in this granular media. Thanks to RCPE theoretical and practical research studies and SRS solution from INDATECH, you can now know all about your powder physical behavior!
Abstract
Understanding the behavior of light in granular media is necessary for determining the sample size, shape, and weight, when probing using fiber optic setups. This is required for a correct estimate of the active pharmaceutical ingredient content in a pharmaceutical blend via near-infrared spectroscopy.
Several strategies to describe the behavior of light in granular and turbid media exist. A common approach is the Monte-Carlo simulation of individual photons and their description using mean free path lengths for scattering and absorption.
In this work, we chose a complementary method by approximating these parameters via real physical counterparts, i.e., the particle size, shape, and density and the resulting chord lengths. Additionally, the wavelength dependence of refractive indices is incorporated. The obtained results were compared with those obtained in an experimental setup that included the SAM-Spec Felin® probe, designed by INDATECH – Chauvin Arnoux, for acquiring Spatially Resolved Spectroscopic measurements of samples.
Therefore, our method facilitates the interpretation of the acquired experimental results by contrasting the optical response, the physical particle attributes, and the simulation results.
Co-Authors:
Dr Otto Scheibelhofer, RCPE, Graz, Austria
Dr Patrick R. Wahl, RCPE, Graz, Austria
Johannes G. Khinast, Institute for Process and Particle Engineering, Graz, Austria
Dr Fabien CHAUCHARD, INDATECH – Chauvin Arnoux, France
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English