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New article on SRS Analysis of powders!

New article on SRS Analysis of powders!

Understanding the behavior of light in granular media is necessary for determining the sample size, shape, and weight, when probing using fiber optic setups. This is required for a correct estimate of the active pharmaceutical ingredient content in a pharmaceutical blend via near-infrared spectroscopy.

Several strategies to describe the behavior of light in granular and turbid media exist. A common approach is the Monte-Carlo simulation of individual photons and their description using mean free path lengths for scattering and absorption.

In this work, we chose a complementary method by approximating these parameters via real physical counterparts, i.e., the particle size, shape, and density and the resulting chord lengths. Additionally, the wavelength dependence of refractive indices is incorporated. The obtained results were compared with those obtained in an experimental setup that included the SAM-Spec Felin® probe, designed by INDATECH – Chauvin Arnoux, for acquiring Spatially Resolved Spectroscopic measurements of samples.

Therefore, our method facilitates the interpretation of the acquired experimental results by contrasting the optical response, the physical particle attributes, and the simulation results.

 

Co-Authors:

Dr Otto Scheibelhofer, RCPE, Graz, Austria

Dr Patrick R. Wahl, RCPE, Graz, Austria

Johannes G. Khinast, Institute for Process and Particle Engineering, Graz, Austria

Dr Fabien CHAUCHARD, INDATECH – Chauvin Arnoux, France

 

More informations: Here