INDATECH

Webinar : Real-time crystallization monitoring using Raman spectroscopy and kinetic models
2023-11-21 16:00 - 17:00 (Europe/Paris) | Webinar
Summary of the webinar
The purity of an active pharmaceutical ingredient (API) is crucial in the pharmaceutical industry. Impurities can alter the effectiveness of the drug and lead to undesirable effects. This is why pharmaceutical regulations impose strict purity standards for APIs, requiring rigorous manufacturing processes and stringent quality controls. Process analytical technology (PAT) serves as a valuable tool for real-time monitoring of product quality attributes, enhancing the overall quality control process.
In this webinar, we will present a collaborative study between Indatech and Rowan University in the USA. The study focused on the utilization of Raman spectroscopy as a PAT tool for the in-line monitoring of the crystallization process of acetaminophen, a commonly used small-molecule API, and curcumin, a simulated impurity with low solubility and co-precipitation tendencies. The Raman results were used to calibrate a population balance model, enabling the prediction of the product’s purity evolution throughout the manufacturing process.
SPEAKER
Mitchell Paolello is a PhD student at Rowan University whose primary research interest is the diagnosis of impurity incorporation mechanisms in pharmaceutical crystallization processes. Most of his work is centered around investigating how impurities incorporate and are retained thermodynamically and kinetically, especially in the context of crystalline solid solutions. He has coauthored a published paper and submitted two papers on case studies of impurity retention mechanisms in both academic and industrial processes. His overall goal is to help improve understanding of the mechanisms in which impurity incorporation and retention occur in pharmaceutical crystallization systems with the purpose of enabling more robust process design. Before coming to Rowan, Mitchell earned his BS in Chemical Engineering at Drexel University and is also currently a co-op in the Solid State and API Engineering division at Boehringer Ingelheim.

IFPAC 2024
2024-03-03 - 2024-03-06 | Bethesda North Marriott, North Bethesda, Maryland, Washington, D.C., USA
Indatech present at the IFPAC 2024 show – from March 3rd to 6th, 2024, in Bethesda, Maryland, USA Dedicated to the latest developments in quality by design, emergent technologies and quality measurements, IFPAC is the essential meeting place for all the pharmaceutical, biotechnological and chemical industries.
At this event, experts and scientists come together to discuss the technologies to improve industrial processes.
As an actor in Industry 4.0, Indatech offers a dynamic approach to production by providing accurate real-time measuring solutions.

Come to our Booths nos. 407 & 409 and discover in person our broad product range: Asuryan, Raman and HypeReal.
Our latest innovations include a new Raman probe capable of cutting sensitivity to external light by 90% and our new flow-cell probe with three adjustable optical paths which is ideal for downstream processes.

Webinar : Fast and non-destructive quality control of lyophilized vials: in-line crack detection and residual moisture prediction
2024-03-12 16:00 - 17:00 | Webinar
Summary of the webinar
The pharmaceutical industry, due to its direct impact on public health, places crucial importance on the quality control of its products. This is particularly significant in the case of lyophilized vaccines, where aspects such as residual moisture content and the physical appearance of lyocakes are of strategic importance, directly impacting the stability and efficacy of the vaccine. The stringent quality control becomes imperative to ensure patient safety and meet the strict regulatory standards governing this delicate industry.

In this webinar, we will present a study conducted in collaboration with a client, whose anonymity, as well as that of the examined product, will be preserved for confidentiality reasons. The study focused on quantifying the residual moisture content in lyophilized vaccine samples and analyzing appearance defects such as cracks using spatially resolved near-infrared spectroscopy (NIR-SRS) and hyperspectral imaging. Sample were measured in the laboratory to demonstrate the capabilities of the SAM-Spec system at-line, with the future intention of real-time inspection of manufactured products directly in-line. Presented products Indatech

HypeReal: benchtop pushbroom imaging system for at-line NIR hyperspectral imaging
SAM-Spec: spatially resolved NIR spectroscopy for high throughput in-line measurements

France Bioproduction Congress
2024-04-03 - 2024-04-04 | Palais des congrès Paris Saclay à Massy, 19 Pl. du Grand Ouest, Massy, 91300, France
Indatech will be at the France Bioproduction Congress –April 3rd to 4th in Paris, France

The France Bioproduction Congress will be held from April 3rd to 4th, 2024 at the Palais des Congrès in Paris. This event brings together more than 450 players from the pharma and biopharma sectors. These decision-makers and actors in French pharmaceutical bioproduction will be meeting for two days of conferences, round-table discussions and practical workshops.

Indatech’s teams are looking forward to meeting you at this event in Paris. We will be there with some fine demonstrations of UV VIS spectroscopy.

Come and discover our solutions such as Asuryan directly at Booth 20!

Indatech is a member of Polepharma and is thus participating in the development of the bioproduction industry. More than 400 industrial companies have also chosen to join Polepharma which groups all the players in the sector: research laboratories, production sites, third-party manufacturers, suppliers and training centers.

The 25th HélioSpir Worskshop: June 11th & 12th, 2024, in Montpellier
2024-06-11 - 2024-06-12 | Agropolis International Montpellier, 1000 Av. Agropolis, Montpellier, 34000
Indatech present at the 25th HélioSPIR Workshop in Montpellier

The 25th HélioSPIR Worskop will be held on June 11th and 12th, 2024, on the Agropolis International site in Montpellier!
Indatech’s team is delighted to be attending to celebrate HélioSPIR’s 20th anniversary on June 11th and 12th, 2024, on the Agropolis International site in Montpellier.
Like every year, the scientific workshop will offer privileged discussions around various topics linked to near-infrared spectroscopy and a chance to learn about the latest work in the community. You will also be able to check out the spectroscopy and hyperspectral imaging equipment from the main manufacturers in the sector, including Indatech.
Lastly, these workshops will be an excellent opportunity to discuss the advances and methods in spectroscopic data analysis.
Don’t miss the conference by Ilys Bichari, PAT Application Engineer at INDATECH, scheduled for 5 PM on Wednesday June 12th, 2024, on “Assessment of enzymatic reactivity on biomass samples by near-infrared imaging.”.

Founded in 2004, the HélioSPIR Association organizes one or more “Scientific Workshops” every year around topics related to Near-Infrared Spectroscopy (NIR) and chemometrics or Machine Learning. The purpose of the association is to federate scientists and users in the French-speaking spectroscopy community within a network to promote the use of near-infrared spectroscopy.

A3P Biotherapy Process Day
2024-11-21 | Lyon – Mercure Château Perrache, Esplanade De La Gare, 12 Cr de Verdun Rambaud, Lyon, 69002, France
A3P Biotherapy Process Day, Indatech Booth 13 – November 21st in Lyon (France)

We are delighted to announce that Indatech will be taking part in the event dedicated to Biotherapy Processes organized by A3P in Lyon on November 21st, 2024. This event aims to bring together the main actors in the field, including start-ups, industrial companies , CDMOs, suppliers and service providers.
Organized following the 2023 event, this day will provide an opportunity to present the work by the GIC and share relevant feedback between the CDMOs and start-ups. Indatech will be there to show you our innovative inspection and analysis solutions for optimizing bioproduction processes.
We invite you to join us in order to explore together the new trends and technologies shaping the future of biotherapies.
We will be present as exhibitors at Booth 15: come and check out our solutions!

Webinar : Raman spectroscopy and Machine Learning as a PAT tool for mAbs bioprocessing
2024-12-10 16:00 - 17:00 | Webinar
Summary of the webinar
In-line Raman spectroscopy, coupled with machine learning tools, enables non-destructive analysis of bioprocesses, such as the production of monoclonal antibodies (mAbs) in cell cultures. Through real-time monitoring of critical process parameters (CPPs) and critical quality attributes (CQAs), such as nutrient and metabolite concentration, viable cell density and mAb concentration, batch reproducibility and yield may be significantly improved.
The developments and results presented in this webinar were carried out in the context of CLIMBIN. CLIMBIN is a collaborative project that aims to provide the bioproduction sector with an innovative solution in process analytical technology (PAT) by molecular optical spectrometry, ready to use and adapted to CHO-type suspension cultures in various types of bioreactors. This real-time monitoring of critical process and quality parameters offers disruptive advantages in terms of control, industrial performance and CSR.
We will present key hardware developments, including innovative probe tips for increased Raman sensitivity, as well as reduced interference from ambient light and media turbidity. An industrial case study on fed batch cell cultures in 10-liter bioreactors will be presented, demonstrating the machine learning model development approach on the path to fully automated process control. Presented products Indatech

Viserion Raman spectrometer
VSP-IM Raman immersion probes

IFPAC 2025
2025-03-02 - 2025-03-05 | Bethesda North Marriott, North Bethesda, Maryland, Washington, D.C., USA
Indatech present at the IFPAC 2025 show – from March 2nd to 5th, 2024, in Bethesda, Maryland, USA

Dedicated to the latest developments in quality by design, emergent technologies and quality measurements, IFPAC is the essential meeting place for all the pharmaceutical, biotechnological and chemical industries.
At this event, experts and scientists come together to discuss the technologies to improve industrial processes.
As an actor in Industry 4.0, Indatech offers a dynamic approach to production by providing accurate real-time measuring solutions.

Come to our Booths nos. 407 & 409 and discover in person our broad product range: Asuryan, Raman and HypeReal.
Our latest innovations include a new Raman probe capable of cutting sensitivity to external light by 90% and our new flow-cell probe with three adjustable optical paths which is ideal for downstream processes.

France Bioproduction 2025
2025-03-19 - 2025-03-20 | Palais des Congrès de Tours, 26. Bd Heurteloup, Tours, 37000, France
Indatech at France Bioproduction: innovative solutions for the biopharmaceutical industry Indatech will be exhibiting at France Bioproduction, the leading event dedicated to the development of the biomanufacturing sector in France. We will be presenting our innovative spectroscopy solutions, designed to optimize manufacturing processes and guarantee real-time quality control in the biopharmaceutical industry.
📍 Join us at France Bioproduction to talk to our experts and discover our technologies for tomorrow’s biomanufacturing!
