Webinar on the use of NIR spatially-resolved spectroscopy for real-time monitoring of low-dose tablet formulation

With this webinar on NIR spatially-resolved spectroscopy, find out how to use NIR SRS spectroscopy as an effective PAT tool for the inspection of tablets with a low-dose formulation.

At this webinar on NIR spatially-resolved spectroscopy, we will be presenting the results of Residence Time Distribution (RTD) experiment. Tracers are used to represent the dynamics of the continuous processes. This is an appropriate methodology allowing control strategies. For this, the tracer must be selected appropriately. However, the selection criteria require similar behavior between the bulk material and the tracer.

Indeed, recent progress in increasing the sensitivity of PAT measurements allows “small” step to be made in the composition of the formulation. In this study our speaker, Carlos Ortega-Zuniga, used a low-dose formulation as the target. He induced small step changes to the API concentration in a continuous process.

For this experiment, the industrial tablet press is equipped with an NIR SRS system. The measuring instrument is therefore positioned after production of the tablets so that the individual tablets can be inspected. After these tests, the NIR SRS system proved sensitive to the capture of step changes of -/+ 0.50 % p/p of API.

To sum up, this work by a postgraduate from Rutgers University has demonstrated that small step changes can be performed to extract the RTD information. As a result, we can confirm that the inspection of low-dose tablets is possible using NIR SRS technology as the PAT tool.

For this purpose CA INDATECH has designed and developed patented technology combining NIR spectroscopy and hyperspectral imaging. This versatile analytical system is ideal for use in the laboratory or on continuous production lines. To learn more about our solution, attend to our webinar on December 15th, at 4 PM.