Webinar on physico-chemical characterization of compaction/granulation products

With this Webinar on physico-chemical characterization, you can find out how to use hyperspectral imaging for quick identification of your samples.

This webinar will focus on physico-chemical characterization using NIR spectroscopy in industrial pharmaceutical, chemical or agri-food environments in order to characterize the granulation process. Also, NIR spectroscopy ensures easier continuous handling and better homogeneity of the blend under consideration. The disparity of the physico-chemical properties of the samples and their diversity require the measurement of several samples in a single operation. Which is why NIR hyperspectral imaging is used with Hypereal.

Then, it will be necessary to discover and characterize all the key steps in the compaction and granulation process during the process development phases. That is why this webinar will show how a hyperspectral imaging system can be used for physico-chemical characterization of these intermediate compacted products by indicating the compaction force applied to a powder blend, the proportion of API in the blend or the granule size.

The results are provided as an image, allowing the operator to gain a fuller understanding for optimization of the process and the machine.

HypeReal can be used to indirectly assess the chemical composition of the samples, their residual moisture content and other critical quality criteria, without destroying or modifying the sample and without using toxic reagents.

The unique HypeReal inspection system developed by INDATECH is an ideal tool for quick, non-destructive, laboratory-scale analyses of solid dosage forms.

Read the Case Study on physico-chemical characterization of powder blends.

Webinar on the use of NIR spatially-resolved spectroscopy for real-time monitoring of low-dose tablet formulation

With this webinar on NIR spatially-resolved spectroscopy, find out how to use NIR SRS spectroscopy as an effective PAT tool for the inspection of tablets with a low-dose formulation.

With this webinar on NIR spatially-resolved spectroscopy, find out how to use NIR SRS spectroscopy as an effective PAT tool for the inspection of tablets with a low-dose formulation.

At this webinar on NIR spatially-resolved spectroscopy, we will be presenting the results of Residence Time Distribution (RTD) experiment. Tracers are used to represent the dynamics of the continuous processes. This is an appropriate methodology allowing control strategies. For this, the tracer must be selected appropriately. However, the selection criteria require similar behavior between the bulk material and the tracer.

Indeed, recent progress in increasing the sensitivity of PAT measurements allows “small” step to be made in the composition of the formulation. In this study our speaker, Carlos Ortega-Zuniga, used a low-dose formulation as the target. He induced small step changes to the API concentration in a continuous process.

For this experiment, the industrial tablet press is equipped with an NIR SRS system. The measuring instrument is therefore positioned after production of the tablets so that the individual tablets can be inspected. After these tests, the NIR SRS system proved sensitive to the capture of step changes of -/+ 0.50 % p/p of API.

To sum up, this work by a postgraduate from Rutgers University has demonstrated that small step changes can be performed to extract the RTD information. As a result, we can confirm that the inspection of low-dose tablets is possible using NIR SRS technology as the PAT tool.

For this purpose CA INDATECH has designed and developed patented technology combining NIR spectroscopy and hyperspectral imaging. This versatile analytical system is ideal for use in the laboratory or on continuous production lines. To learn more about our solution, attend to our webinar on December 15th, at 4 PM.